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pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may possibly increase the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will minimize the extent or influence of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metab